Transform your delicate ADC molecule into a stable quality product with our expert CRO formulation services! ProJect Pharmaceutics is a CRO specialized in formulation and lyophilization process development for antibody-drug conjugates. We have been developing ADCs in our dedicated safety laboratories for > 15 years and have seen all generations of ADCs on our workbench. By combining protein formulation and process know-how with cytotoxic drug expertise the company holds unique assets to develop ADC drug products. By means of modern and advanced screening technologies we accelerate formulation development and target a formulation that suits antibody, linker and payload to stabilize the ADC at its “sweet spot”.
Sustainable formulation solutions for a cytotoxic small molecule: impossible? No! Partner with us to meet the increasing demand to use more environmentally friendly solvents!
As an expert in formulation and process development for small molecule drugs, we encounter many drugs that have solubility and stability issues and drug formulation development struggles i.a. with the following pain points: a) Finding an appropriate organic solvent / solvent mixture that can dissolve the API without compromising its stability, b) many organic solvents are toxic and regulatory agencies have strict limits on the permissible levels of residual solvents in pharmaceutical products, c) removing solvents to acceptable levels can be technically challenging and costly. On top, there is increasing ecologic and social pressure to use greener, more sustainable solvent systems. Finding suitable alternatives to traditional organic solvents that are environmentally friendly can be difficult. Here at ProJect Pharmaceutics CRO we take on the challenge together with you, we are committed to using greener solvents wherever possible:
careful selection of the least toxic & most effective solvent for the specific API
using mixtures of solvents to enhance solubility & stability profiles
utilizing advanced formulation techniques to minimize solvent use
exploring greener solvent alternatives to reduce environmental impact and improve safety.
If you also want to partner with us to benefit from reduced toxicity, biodegradability, lower volatility and renewable sources when using greener solvents, contact us.
